As early as 1450, old writings mention a chapel in Grootlo. Like other religious buildings, the chapel suffered from the religious troubles of the late 16th and early 17th centuries. In 1799, French soldiers destroyed a statue of Our Lady and the only bell. In 1833, the chapel was restored. A few years later, the dilapidated tower was pulled down and the rest of the roof was repaired. In 1936, the construction of the present church started.